How long does Modafinil stay in your system?


How long does Modafinil stay in your system?

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How long does Modafinil stay in your system?

Modafinil stays in the system for 4-7 days, and there are various factors that affect how long the nootropic stays in our system, such as age, dosage, alcohol, kidney and liver function, and high-fat food.

Modafinil is a medicine that is used to treat various sleep disorders, such as Sleep Apnea, Shift Work Sleep Disorder, and Narcolepsy. It is also used as a cognitive enhancer to improve alertness, focus, and concentration. 

You, too, can embark on the path of enhanced wakefulness and cognitive functioning by ordering Modafinil tablets from Healthmatter at an affordable price. With a vision of making healthcare services affordable and convenient for people, they offer genuine and quality medication and services to all. 

Now, many people who take Modafinil may wonder how long this nootropic stays in their system, but the answer to this question is complex because several factors can affect its longevity.

In this blog, we’ll explore how long Modafinil stays in our system, and the factors that can impact its duration of action. 

What Is Modafinil – An Overview Of The Popular Nootropic 

Modafinil is a wakefulness-promoting agent (eugeroic) for oral administration. It was developed in the 1970s and approved in the United States for medical use in 1998. Modafinil is sold under various brand names, such as Modvigil and Modalert [1]. 

Modafinil Mechanism Of Action:

The working mechanism of Modafinil includes the secretion of neurotransmitters, such as orexin, dopamine, histamine, norepinephrine, glutamate, and serotonin. Elevating these neurotransmitters improves wakefulness and the overall function of the brain. 

Modafinil works on the brain to secrete orexin, which is involved in improving the mood of the user. This also plays a key role in helping Modafinil improve the signs of anxiety, stress, and depression. 

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How Long Does Modafinil Take To Work?

Modafinil usually starts working within 30-60 minutes after ingesting it. This makes it an ideal choice for people who need a quick boost of focus and energy, especially those with sleep disorders [2]. 

Modafinil Half-Life

The half-life of Modafinil ranges between 12-15 hours for most patients. Modafinil is readily absorbed after oral administration and reaches its maximum plasma concentration within 2-4 hours. It is metabolized through hepatic pathways and excreted in the form of metabolites through the kidneys [3].

Half-life is defined as the time required for a drug’s active compound to reduce by half in the body.

How Long Does Modafinil Stay In Your System?

Modafinil stays in the system much longer, even if its effects decline. It takes about 4-7 days for Modafinil to be completely eliminated from the system [4].

                              Hours                  Amount of Modafinil 
15th hour 65 mg (50% left)
30th hour 32.5 mg (25% left)
45th hour 16.25 mg (12.5% left)
60th hour 8.125 mg (6.25% left)
75th hour 4.063 mg (3.125% left)
90th hour 2.031 mg (1.56% left)
105th hour 1.016 mg (0.78% left)

Factors Contributing To How Long Does Modafinil Last In Your System? 

Five factors contributing to how long Modafinil lasts in your system are as follows –

Age –

With age, the metabolism of a person reduces. Therefore, older people may have more prolonged effects from this nootropic than young people.

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Liver and Kidney problems –

Modafinil is metabolized in the liver, therefore, suffering from any hepatic disorder can result in a slower metabolic rate, and people with kidney dysfunction may also experience a prolonged duration of action of Modafinil as the body takes longer to eliminate the metabolites from the system.


The Modafinil dosage can determine how long it stays in the body. A higher dosage of the nootropic stays longer in the system compared to a lower dosage.

High-Fat Food- 

Taking Modafinil after a heavy meal can make it take longer to work and reduce its effectiveness.

Alcoholic beverages- 

The consumption of alcohol while taking Modafinil can affect how the nootropic works, thus making it less effective. It can result in various side effects, such as dizziness, low blood pressure, fainting, and headaches.

Does Modafinil Show Up On Drug Tests?

Modafinil drug tests can be performed by two bodily fluids, namely, blood and urine.

Modafinil urine tests are designed to track the metabolites of the nootropic several hours following the ingestion or administration. They are less expensive than blood tests.

Blood tests are designed to accurately identify Modafinil within 2-12 hours of ingestion. And unlike urine tests, the samples in the blood tests are less susceptible to tampering, making it the most accurate test. However, blood tests for Modafinil are far more expensive than urine tests. A detailed report on the Modafinil drug test by Healthnaturo suggests that one should discontinue the intake of Nootropic 3 to 4 days before the drug test to ensure that the results come back negative. 

With the high levels of specificity offered by these tests, it is unlikely to generate false positive or negative results.

  • False positive – The drug test says that Modafinil is present in your system, but it’s actually not there.
  • False Negative – The drug test says Modafinil is not present in your system, but it’s actually there.
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In two separate clinical studies, 20 male participants were given Modafinil 100 mg, It took 72-80 hours for Modafinil to be completely undetectable in their urine samples [5] [6].

How To Remove Modafinil From The System Safely

To remove Modafinil safely from the system, an individual needs to reduce the intake or dosage of the nootropic for a specific time. This will allow your body to adjust to less medication.

Removing this medicine from the system may cause some withdrawal symptoms. Six withdrawal symptoms of Modafinil are –

  • Low energy
  • Sleep disorder
  • Poorer concentration
  • Shortness of breath
  • Fatigue
  • Depression.

How Long Does Modafinil Stay In Your System – Conclusion

Modafinil has gained popularity as the go-to drug for reducing fatigue and promoting alertness. Based on our findings, we can summarize the blog with the following key points –

  • The onset of action of Modafinil is 30-60 minutes.
  • The half-life of this medication ranges between 12-15 hours.
  • Modafinil lasts in the system for 4 to 7 days.
  • There are various factors that affect how long the nootropic stays in our system.
  • Modafinil can only be detected through blood and urine tests. 


How Long Does It Take For Modafinil To Wear Off?

Modafinil takes 4-7 days to wear off completely.

Is it safe to take Modafinil every day?

Yes, it is safe to take Modafinil every day.

Does Modafinil improve mood?

Yes, Modafinil has mood-enhancing effects.

How fast does Modafinil work?

Modafinil starts to show its effect within 30-60 minutes after administration.

What does Modafinil do in the brain?

Modafinil increases the levels of certain neurotransmitters (dopamine, orexin, histamine, glutamate, and serotonin) in the brain.


  1. Modafinil, Wikipedia.
  2. Provigil (Modafinil), medicalnewstoday.
  3. Practical Use and Risk of Modafinil, a Novel Waking Drug, NCBI.
  4. Drug Elimination Calculator, observablehq.
  5. A novel study of screening and confirmation of modafinil, adrafinil, and their metabolite modafinilic acid under EI-GC-MS and ESI-LC-MS-MS ionization, NCBI.
  6. Detection of modafinil in human urine by gas chromatography-mass spectrometry, NCBI.

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